Molecular Interaction Core

 

     This core in located at the Research Institute for Children (Children’s Hospital Campus) and utilizes Biacore technology (www.biacore.com) to study intermolecular interactions in real time.

     Using the principle of surface plamon resonance, this technique can be used to determine association and dissociation kinetics, and perform concentration analyses. This technology has proven extremely useful in determining affinities of monoclonal antibodies and of polyclonal antisera.

     Because antibody affinity is often a correlate of protective activity, this presents a method for analyzing the quality of the antibody response elicited by experimental vaccines. Other uses for this technique include defining interactions between peptides and other low molecular weight ligands and larger molecules including antibodies, receptors, and enzymes. More details about this methodology may be obtained on the company’s website.

 

Location:

Children's Hospital